HMB (short for β-hydroxy β-methylbutyrate) is a metabolite of the amino acid leucine. Approximately 5% of dietary leucine oxidizes into HMB, and compared to leucine, HMB appears to be significantly stronger gram for gram in reducing the rate of muscle protein breakdown. However, it is less effective than leucine in promoting muscle protein synthesis.
Increased intake of HMB mitigates damage to muscle cell membranes, thus acting against the catabolic hormone cortisol, thereby increasing anabolism. Its main function is to enhance regeneration and increase the utilization of proteins needed for muscle building. Additionally, HMB has numerous positive effects, such as maintaining nitrogen balance, protecting and regenerating muscle mass, improving the growth of muscle mass and strength, reducing body fat, reducing exercise-induced muscle breakdown, and even aiding the body in adapting to increased physical stress.
Effects of HMB:
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